Easiest is by taxi, fare is roughly $35-40. Cheapest is AirTrain/subway $7.25; take AirTrain from terminal to Jamaica Station, take E subway to Roosevelt Ave/Jackson Hgts, transfer to the inbound #7 subway to Queensboro Plaza, walk east on 27th St, left on 41st Ave, right on Crescent St to hotel.
Easiest is by taxi, fare is