You can take Boltbus or Vamoose bus from outside Penn Station to Philadelphia (about $20) or Amtrak train from Penn Station to Philadelphia (about $30-$40) and then local transportation in Philly to your location. You can reach Penn Station from JFK by taxi ($45+tolls+tip), NYAS express bus ($15) or public transportation; Airtrain from terminal to Jamaica Station and either LIRR or E subway to Penn Station. LIRR is more expensive than subway but easier if you have luggage and a bit faster.
You can take Boltbus or