With tip and toll, a taxi will cost about $60. At that hour, the taxi ride could easily take more than one hour. If I were not carrying a lot of luggage, I would opt for the AirTrain to Jamaica Station ($5.00), and then the Long Island Rail Road from Jamaica to Penn Station ($6.25 on weekdays; $3.75 on weekends if one selects the "City Ticket" option on the LIRR ticket-vending machine). Total travel time should be 50-60 minutes.
With tip and toll, a taxi