Taxi will take you direct, $45+tolls+tip. ONLY take the NYC yellow taxi at ground transportation, do not accept offers from others as they will rip you off. By AirTrain/subway ($7.25); take AirTrain from your terminal to Jamaica Station, transfer to E subway to 7th Ave/53rd St, walk south one block on 7th Ave to 52nd St, turn right to your hotel just past the next intersection with Broadway .
Taxi will take you direct,