You could take a taxi, cost would probably be around $100+. Ask the hotel is they have a shuttle from the Secaucus Junction train station and if they do, you can take the NYAS express bus to Penn Station, or Airtrain from terminal to Jamaica Station and either E subway or LIRR to Penn Station. Then take pretty much any NJ Transit train to Secaucus Junction, total cost around $20. If no hotel shuttle you can still take a cab from station to hotel.
You could take a taxi, cost